It's 2004. DEA agent Art Keller has been fighting the war on drugs for thirty years in a blood feud against Adán Barrera, the head of El Federación, the world's most powerful cartel, and the man who brutally murdered Keller's partner. Finally putting Barrera away cost Keller dearly--the woman he loves, the beliefs he cherishes, the life he wants to lead. Then Barrera gets out, determined to rebuild the empire that Keller shattered. Unwilling to live in a world with Barrera in it, Keller goes on a ten-year odyssey to take him down.