When New Orleans Police Detective Danny Fisher stops a brilliant thief from getting away with a multimillion-dollar heist, the thief's girlfriend is accidentally killed. A year later Danny is about to have the worst day of his life. After escaping from prison, the theif, who is also an internationally-known terrorist, named Miles Jackson, kidnaps Danny's girlfriend Molly and forces him into '12 Rounds' of dangerous games carefully plotted throughout the streets of New Orleans. Danny struggles to keep focus while the clock ticks and he deals with the consequences that accompany each one of these 'rounds.' Miles does his best to derail him from rescuing the love of his life before it's too late.